Women’s health during the menopausal transition
In this study, changes and relationships between biological, psychological and social variables in healthy women aged 40-55 in the perimenopause are examined from the perspective of healthy aging. Particular attention is paid to hormonal and (epi-)genetic changes in the aging process of women. The menopausal transition constitutes a natural process of development and portrays a significant period in a woman's lifeline. It is accompanied by endocrine changes, by the loss of reproductive function and often by various physical and psychological symptoms. Within this longitudinal study, the comparison of hormone profiles, the examination of genetic dispositions, and the assessment of dispositional and variable psychosocial constructs are made to receive a better understanding of this multi-faceted process of change and its associated challenges and needs. Further information can be found here.
Men’s health 40+ longitudinal study
The focus of the study is to expand the previously cross-sectional study to a longitudinal study with a 3-year follow-up. This enables causal inference. Further specific epigenetic and genetic markers were added to include DNA polymorphisms of the Androgen Receptor Gene and the Glucocorticoid Receptor Gene, as well as the methylation status for the Glucocorticoid Receptor Gene. The follow-up also includes, in addition to the laboratory hormone status, a two-day hormone profile for Cortisol and Testosterone and an Eye-Tracking paradigm to investigate emotion recognition and scanning patterns.
Biopsychosocial factors of healthy aging - Women’s health study 40+
In this cross-sectional study, we investigated a total of 245 healthy women aged 40 to 73. The study was based on a biopsychosocial model of health and healthy aging. Preliminary results support the assumption of an interplay between age-related changes in biological factors (e.g. hormones) and psychosocial aspects (e.g. relationship quality and optimism) on health in middle-aged and older women. Further information can be found here.
Men’s stress study 40+
The focus of the assessment in the study Men’s Stress 40+ refers to 124 medication-free men who show signs of vital exhaustion and depressive mood, but no physical illness or mental disorders. It was tested whether they differ in their hormonal profiles from men recruited in study Men’s Health 40+. This additional data set allows us to identify predictors of health impairment due to subjectively described mental burden.
Project status: completed (2015-2017)
Contact: Prof. Dr. Ulrike Ehlert
Biopsychosocial factors of healthy aging - Men’s health 40+
The study focuses on healthy men between 40 and 75 years of age. By considering psychological, social and biological factors, the study includes all factors of the biopsychosocial model. This large-scale cross-sectional study aims to identify factors of health and the maintaining of health through older age; more specific the hormonal profile of middle aged and older men. Participants complete a broad battery of questionnaires and an additional laboratory appointment to measure hormone status, as well as physiological data.